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Test likelihood of adverse effects from medication

Cypass

Medication can have undesirable side effects. Different medications can also interact with one another if you have to take several at the same time. The new Cypass, Cypass Extended and Statins tests check your compatibility with certain medications. The Cypass and Cypass Extended tests also provide information about potential drug interactions.

Cypass genetic test assesses suitability of medication

The Federal Office of Public Health estimates that 40,000–45,000 hospital admissions every year in Switzerland are linked to adverse reactions to medication.

The effect of any medication is influenced by metabolic processes: how the body converts and eliminates substances. The new Cypass genetic test assesses the metabolic processes and 82 clinically significant genes that are involved in breaking down and processing common medications.

The test results can be used to predict potential interactions between drugs and minimise the side effects. They tell you how quickly your body metabolises medication. You and your doctor will then be able to find the right medication for you.

The genetic test is simple and does not take long: your GP simply takes a saliva sample.

Limits of the test

Metabolic processes can also be influenced by foodstuffs such as grapefruit or pineapple, drinks including coffee, tea and alcohol, and environmental factors. Your state of health and diet are as important as genetic factors. The test can be used to avoid many, but not all, of the unpleasant side effects of medication.

Clinical studies

Genetic factors that influence drug metabolism are clinically relevant, as has been demonstrated in a variety of scientific literature.

Cypass Extended – extended genetic tests on suitability of medication

The basic Cypass genetic test assesses the metabolic processes of 16 genes and 97 genetic variants. The Cypass Extended genetic test evaluates 25 genes and 127 genetic variants associated with processing medication and adverse effects. The test provides information about specific medication types, including anaesthetics, cancer treatments and medication for certain autoimmune disorders.

The test results can be used to predict potential interactions between drugs and minimise the side effects. They tell you how quickly your body metabolises medication. You and your doctor will then be able to find the right medication for you.

The genetic test is simple and does not take long: your GP simply takes a saliva sample.

Limits of the test

Metabolic processes can also be influenced by foodstuffs such as grapefruit or pineapple, drinks including coffee, tea and alcohol, and environmental factors. Your state of health and diet are as important as genetic factors. The test can be used to avoid many, but not all, of the unpleasant side effects of medication.

Clinical studies

Genetic factors that influence drug metabolism are clinically relevant, as has been demonstrated in a variety of scientific literature.

Genetic test to determine suitability of medication for reducing cholesterol levels (statins)

Statins are the most commonly prescribed medication in Switzerland. Statins are used to reduce blood fat levels, especially "bad" cholesterol, by 30% to 50%; to reduce the risk of cardiovascular disease, and as a preventative measure for high-risk individuals. However, the effectiveness of statins is affected by certain genetic variants that are part of the patient's DNA.

Taking statins can have side effects, the most common being mild to severe muscle weakness/pain. 10–15% of patients who take statins experience muscle weakness/pain. The side effects are influenced by the patient's age and BMI, but also the type of statin and dosage, interactions with other medications and genetic predispositions.

By identifying the genetic variants that affect the metabolism and toxicity of statins, doctors are able to provide the best possible treatment with minimal side effects.

Limits of the test

The effectiveness of statins can be affected by certain foodstuffs such as grapefruit and by other medications. In addition to your genetic makeup, your general health and diet have a significant impact on the effectiveness of the treatment.

The Statins test indicates whether you are likely to experience muscle pain when taking the medication. However, the test does not provide any information about whether you are at greater risk of experiencing other side effects when taking statins, such as increased blood sugar levels, diabetes or memory loss.

Clinical studies

Genetic factors that influence drug metabolism are clinically relevant, as has been demonstrated in a variety of scientific literature.

Costs covered by Helsana

Costs covered by PRIMEO supplementary insurance

If you have PRIMEO supplementary insurance and take regular medication, Helsana will cover 90% of the test costs charged by our partner Gene Predictis. Supplementary insurance pays up to a total of CHF 5,000 per calendar year for innovative forms of diagnosis and treatment. Helsana will be invoiced directly for your test. This cover only applies to holders of PRIMEO insurance who regularly take standard medication (Cypass), are medication for cancer and/or autoimmune disorders (Cypass Extended), or statins (Statins test).

Costs covered without PRIMEO supplementary insurance

This laboratory test is not covered by basic insurance. For policyholders who do not have supplementary insurance, Helsana has agreed a preferential price with our partner firm Gene Predictis. Customers who do not have PRIMEO supplementary insurance will receive a discount of 20% on the official test price. The policyholder will be invoiced directly for the test.

Advice from your general practitioner

If you are interested in taking one of these tests, please consult your doctor. Your doctor must always prescribe any analysis of blood, tissue and saliva samples. Gene Predictis will send the test results direct to your doctor.

Discounts on other Gene Predictis services

Helsana Group policyholders benefit from a 10% discount on other laboratory services from partner firm Gene Predictis.

More information